At the moment, the cheapest time of year to travel to Rome is April/2020. You will pay the most in May/2020.
KLM, Air France, Norwegian, Delta and Alitalia fly direct to Rome from the United States of America.
Finnair is the cheapest airline that flies from the United States of America to Rome.
The best airline to fly from the United States of America to Rome is Qatar Airways. KLM is the best for direct flights. Norwegian is the best budget airline.